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KMID : 1146620220110020043
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Journal of Korean Academy of Advanced General Dentistry
2022 Volume.11 No. 2 p.43 ~ p.48
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Bone Response to the Magnesium Membrane
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Song Su-Min
Lee Won
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Abstract
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When performing bone graft in dentistry, barrier membrane such as Polytetrafluoroethylene (PTFE) and Titanium membrane have been routinely used to prevent soft tissue from invading bone defects or bone graft sites. Recently studies are focusing on the use of magnesium membranes, and despite the fact that magnesium is metal, there have been reports that magnesium membranes can be helpful in bone formation while being resorbable and degraded in vivo. To observe the effects of PTFE and magnesium membranes, 4 holes(ø 5 mm) were created on both sides of the exposed rabbit’s skull. The bone defect areas were covered with the existing commercially available membranes; PTFE membrane, Titanium mesh membrane, and Magnesium membrane. Tissue samples were made after sacrificing rabbits at week 6 (T1) and week 12 (T2) and compared with the control group in which the defects were not covered with a membrane. Overall, the measured total bone area increased at week 12 (T2) compared to week 6 (T1), but in the case of Titanium (Tm) group, it decreased at week 12. The bone ratio (% area) showed a relatively low value in the Magnesium (Mg) group. The bone ratio of the Mg group and the Tm group increased while the PTFE (Tf) group and the control group tended to decrease at the week 12. As a result of TRAP staining, all three groups using barrier membranes tended to decrease the number of osteoclasts at week 12 compared to week 6, and Mg group showed higher osteoclasts expression than other groups, but there was no significance between groups. Therefore, the magnesium barrier membrane is considered to promote osteoclast activity and formation of bone.
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KEYWORD
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Magnesium, Guided bone regeneration (GBR), Barrier membrane, Tartrate-resistant acidic phosphatase (TRAP)
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